diff --git a/.CMake/alg_support.cmake b/.CMake/alg_support.cmake
index c24ba6407..db1088735 100644
--- a/.CMake/alg_support.cmake
+++ b/.CMake/alg_support.cmake
@@ -27,8 +27,8 @@ if(OQS_DIST_X86_64_BUILD OR OQS_USE_AVX2_INSTRUCTIONS)
 endif()
 endif()
 
-# BIKE is not supported on Windows and 32-bit ARM
-cmake_dependent_option(OQS_ENABLE_KEM_BIKE "Enable BIKE algorithm family" ON "NOT WIN32; NOT ARCH_ARM32v7; NOT ARCH_X86" OFF)
+# BIKE is not supported on Windows, 32-bit ARM and S390X (big endian)
+cmake_dependent_option(OQS_ENABLE_KEM_BIKE "Enable BIKE algorithm family" ON "NOT WIN32; NOT ARCH_ARM32v7; NOT ARCH_X86; NOT ARCH_S390X" OFF)
 cmake_dependent_option(OQS_ENABLE_KEM_bike_l1 "" ON "OQS_ENABLE_KEM_BIKE" OFF)
 cmake_dependent_option(OQS_ENABLE_KEM_bike_l3 "" ON "OQS_ENABLE_KEM_BIKE" OFF)
 
diff --git a/.travis.yml b/.travis.yml
index f6cb2f51e..a280490e6 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -17,5 +17,5 @@ jobs:
       compiler: gcc
       if: NOT branch =~ /^ghactionsonly-/
       script:
-        - mkdir build && cd build && cmake -DOQS_ENABLE_KEM_BIKE=OFF -GNinja .. && cmake -LA .. && ninja
+        - mkdir build && cd build && cmake -GNinja .. && cmake -LA .. && ninja
         - cd build & ninja run_tests