diff --git a/acinclude.m4 b/acinclude.m4
index 4464ac49054..5adf014d3d1 100644
--- a/acinclude.m4
+++ b/acinclude.m4
@@ -696,8 +696,11 @@ AC_MSG_CHECKING(for python build information)
    ax_python_bin=$PYTHON_BIN
    if test x$ax_python_bin != x; then
       AC_CHECK_LIB($ax_python_bin, main, ax_python_lib=$ax_python_bin, ax_python_lib=no)
+      if test `echo ${host} | grep '.*-darwin.*'`; then
+        python_prefix=/System/Library/Frameworks/Python.framework/*/
+      fi
       AC_CHECK_HEADER([$ax_python_bin/Python.h],
-      [[ax_python_header=`locate $ax_python_bin/Python.h | sed -e s,/Python.h,,`]],
+      [[ax_python_header=`locate $python_prefix$ax_python_bin/Python.h | sed -e s,/Python.h,,`]],
       ax_python_header=no)
       if test $ax_python_lib != no; then
         if test $ax_python_header != no; then