diff --git a/CMakeLists.txt b/CMakeLists.txt
index 787a587a12c..f19dfdea911 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -233,7 +233,11 @@ if(WITH_CORE)
     set (POSTGRESQL_PREFIX "" CACHE PATH "Path to POSTGRESQL base directory")
   endif()
 
-  set (WITH_QSPATIALITE FALSE CACHE BOOL "Determines whether QSPATIALITE sql driver should be built")
+  # try to configure and build POSTGRESQL support
+  set (WITH_SPATIALITE TRUE CACHE BOOL "Determines whether Spatialite support should be built (required for spatialite, virtual, wfs providers)")
+  if (WITH_SPATIALITE)
+      set (WITH_QSPATIALITE FALSE CACHE BOOL "Determines whether QSPATIALITE sql driver should be built")
+  endif()
 
   set (WITH_ORACLE FALSE CACHE BOOL "Determines whether Oracle support should be built")
   if(WITH_ORACLE)
@@ -390,7 +394,10 @@ if(WITH_CORE)
     find_package(Poly2Tri REQUIRED)
   endif()
 
-  find_package(SpatiaLite REQUIRED)
+  if (WITH_SPATIALITE)
+    find_package(SpatiaLite REQUIRED)
+    set (HAVE_SPATIALITE TRUE)
+  endif()
 
   if (NOT PROJ_FOUND OR NOT GEOS_FOUND OR NOT GDAL_FOUND)
     message (SEND_ERROR "Some dependencies were not found! Proj: ${PROJ_FOUND}, Geos: ${GEOS_FOUND}, GDAL: ${GDAL_FOUND}")
diff --git a/cmake_templates/qgsconfig.h.in b/cmake_templates/qgsconfig.h.in
index 41a179b97fa..98cdc28cfeb 100644
--- a/cmake_templates/qgsconfig.h.in
+++ b/cmake_templates/qgsconfig.h.in
@@ -57,6 +57,8 @@
 
 #cmakedefine HAVE_GUI
 
+#cmakedefine HAVE_SPATIALITE
+
 #cmakedefine HAVE_POSTGRESQL
 
 #cmakedefine HAVE_ORACLE
diff --git a/src/app/CMakeLists.txt b/src/app/CMakeLists.txt
index 05ffc1fa189..3280df434af 100644
--- a/src/app/CMakeLists.txt
+++ b/src/app/CMakeLists.txt
@@ -226,8 +226,6 @@ set(QGIS_APP_SRCS
   pluginmanager/qgspluginsortfilterproxymodel.cpp
   pluginmanager/qgspluginitemdelegate.cpp
 
-  qgsnewspatialitelayerdialog.cpp
-
   qgssettingstree.cpp
   qgsvariantdelegate.cpp
   qgscrashhandler.cpp
@@ -235,6 +233,13 @@ set(QGIS_APP_SRCS
   mesh/qgsmeshcalculatordialog.cpp
 )
 
+if (WITH_SPATIALITE)
+  set(QGIS_APP_SRCS
+    ${QGIS_APP_SRCS}
+    qgsnewspatialitelayerdialog.cpp
+  )
+endif()
+
 if (WITH_GEOREFERENCER)
   set(QGIS_APP_SRCS
     ${QGIS_APP_SRCS}
diff --git a/src/app/qgisapp.cpp b/src/app/qgisapp.cpp
index 086a3bd34b2..26de5456e05 100644
--- a/src/app/qgisapp.cpp
+++ b/src/app/qgisapp.cpp
@@ -472,11 +472,14 @@ Q_GUI_EXPORT extern int qt_defaultDpiX();
 
 #include <sqlite3.h>
 
+#ifdef HAVE_SPATIALITE
 extern "C"
 {
 #include <spatialite.h>
 }
 #include "qgsnewspatialitelayerdialog.h"
+#endif
+
 #include "qgsnewgeopackagelayerdialog.h"
 
 #ifdef WITH_BINDINGS
@@ -2648,7 +2651,9 @@ void QgisApp::createActions()
 
   connect( mActionDataSourceManager, &QAction::triggered, this, [ = ]() { dataSourceManager(); } );
   connect( mActionNewVectorLayer, &QAction::triggered, this, &QgisApp::newVectorLayer );
+#ifdef HAVE_SPATIALITE
   connect( mActionNewSpatiaLiteLayer, &QAction::triggered, this, &QgisApp::newSpatialiteLayer );
+#endif
   connect( mActionNewGeoPackageLayer, &QAction::triggered, this, &QgisApp::newGeoPackageLayer );
   connect( mActionNewMemoryLayer, &QAction::triggered, this, &QgisApp::newMemoryLayer );
   connect( mActionNewVirtualLayer, &QAction::triggered, this, &QgisApp::addVirtualLayer );
@@ -2661,7 +2666,9 @@ void QgisApp::createActions()
   connect( mActionAddRasterLayer, &QAction::triggered, this, [ = ] { dataSourceManager( QStringLiteral( "gdal" ) ); } );
   connect( mActionAddMeshLayer, &QAction::triggered, this, [ = ] { dataSourceManager( QStringLiteral( "mdal" ) ); } );
   connect( mActionAddPgLayer, &QAction::triggered, this, [ = ] { dataSourceManager( QStringLiteral( "postgres" ) ); } );
+#ifdef HAVE_SPATIALITE
   connect( mActionAddSpatiaLiteLayer, &QAction::triggered, this, [ = ] { dataSourceManager( QStringLiteral( "spatialite" ) ); } );
+#endif
   connect( mActionAddMssqlLayer, &QAction::triggered, this, [ = ] { dataSourceManager( QStringLiteral( "mssql" ) ); } );
   connect( mActionAddDb2Layer, &QAction::triggered, this, [ = ] { dataSourceManager( QStringLiteral( "DB2" ) ); } );
   connect( mActionAddOracleLayer, &QAction::triggered, this, [ = ] { dataSourceManager( QStringLiteral( "oracle" ) ); } );
@@ -2671,7 +2678,9 @@ void QgisApp::createActions()
   connect( mActionAddVectorTileLayer, &QAction::triggered, this, [ = ] { dataSourceManager( QStringLiteral( "vectortile" ) ); } );
   connect( mActionAddPointCloudLayer, &QAction::triggered, this, [ = ] { dataSourceManager( QStringLiteral( "ept" ) ); } );
   connect( mActionAddWcsLayer, &QAction::triggered, this, [ = ] { dataSourceManager( QStringLiteral( "wcs" ) ); } );
+#ifdef HAVE_SPATIALITE
   connect( mActionAddWfsLayer, &QAction::triggered, this, [ = ] { dataSourceManager( QStringLiteral( "WFS" ) ); } );
+#endif
   connect( mActionAddAfsLayer, &QAction::triggered, this, [ = ] { dataSourceManager( QStringLiteral( "arcgisfeatureserver" ) ); } );
   connect( mActionAddDelimitedText, &QAction::triggered, this, [ = ] { dataSourceManager( QStringLiteral( "delimitedtext" ) ); } );
   connect( mActionAddVirtualLayer, &QAction::triggered, this, [ = ] { dataSourceManager( QStringLiteral( "virtual" ) ); } );
@@ -3428,7 +3437,9 @@ void QgisApp::createToolBars()
   bt = new QToolButton();
   bt->setPopupMode( QToolButton::MenuButtonPopup );
   bt->addAction( mActionNewVectorLayer );
+#ifdef HAVE_SPATIALITE
   bt->addAction( mActionNewSpatiaLiteLayer );
+#endif
   bt->addAction( mActionNewGeoPackageLayer );
   bt->addAction( mActionNewMemoryLayer );
 
@@ -3929,8 +3940,10 @@ void QgisApp::setTheme( const QString &themeName )
 #ifdef HAVE_POSTGRESQL
   mActionAddPgLayer->setIcon( QgsApplication::getThemeIcon( QStringLiteral( "/mActionAddPostgisLayer.svg" ) ) );
 #endif
+#ifdef HAVE_SPATIALITE
   mActionNewSpatiaLiteLayer->setIcon( QgsApplication::getThemeIcon( QStringLiteral( "/mActionNewSpatiaLiteLayer.svg" ) ) );
   mActionAddSpatiaLiteLayer->setIcon( QgsApplication::getThemeIcon( QStringLiteral( "/mActionAddSpatiaLiteLayer.svg" ) ) );
+#endif
   mActionAddMssqlLayer->setIcon( QgsApplication::getThemeIcon( QStringLiteral( "/mActionAddMssqlLayer.svg" ) ) );
   mActionAddDb2Layer->setIcon( QgsApplication::getThemeIcon( QStringLiteral( "/mActionAddDb2Layer.svg" ) ) );
 #ifdef HAVE_ORACLE
@@ -4052,7 +4065,9 @@ void QgisApp::setTheme( const QString &themeName )
   mActionAddXyzLayer->setIcon( QgsApplication::getThemeIcon( QStringLiteral( "/mActionAddXyzLayer.svg" ) ) );
   mActionAddVectorTileLayer->setIcon( QgsApplication::getThemeIcon( QStringLiteral( "/mActionAddVectorTileLayer.svg" ) ) );
   mActionAddWcsLayer->setIcon( QgsApplication::getThemeIcon( QStringLiteral( "/mActionAddWcsLayer.svg" ) ) );
+#ifdef HAVE_SPATIALITE
   mActionAddWfsLayer->setIcon( QgsApplication::getThemeIcon( QStringLiteral( "/mActionAddWfsLayer.svg" ) ) );
+#endif
   mActionAddAfsLayer->setIcon( QgsApplication::getThemeIcon( QStringLiteral( "/mActionAddAfsLayer.svg" ) ) );
   mActionAddToOverview->setIcon( QgsApplication::getThemeIcon( QStringLiteral( "/mActionInOverview.svg" ) ) );
   mActionAnnotation->setIcon( QgsApplication::getThemeIcon( QStringLiteral( "/mActionAnnotation.svg" ) ) );
@@ -5279,8 +5294,13 @@ void QgisApp::about()
     versionString += QStringLiteral( "</td></tr><tr>" );
 
     // spatialite
-    versionString += QStringLiteral( "<td>%1</td><td colspan=\"3\">%2</td>" ).arg( tr( "SpatiaLite version" ), spatialite_version() );
-    versionString += QLatin1String( "</tr><tr>" );
+    versionString += QStringLiteral( "<td>%1</td><td colspan=\"3\">" ).arg( tr( "SpatiaLite version" ) );
+#ifdef HAVE_SPATIALITE
+    versionString += QStringLiteral( "%1</td>" ).arg( spatialite_version() );
+#else
+    versionString += tr( "No support" );
+#endif
+    versionString += QStringLiteral( "</td></tr><tr>" );
 
     // QWT
     versionString += QStringLiteral( "<td>%1</td><td colspan=\"3\">%2</td>" ).arg( tr( "QWT version" ), QWT_VERSION_STR );
@@ -6732,11 +6752,13 @@ void QgisApp::newMemoryLayer()
   }
 }
 
+#ifdef HAVE_SPATIALITE
 void QgisApp::newSpatialiteLayer()
 {
   QgsNewSpatialiteLayerDialog spatialiteDialog( this, QgsGuiUtils::ModalDialogFlags, QgsProject::instance()->defaultCrsForNewLayers() );
   spatialiteDialog.exec();
 }
+#endif
 
 void QgisApp::newGeoPackageLayer()
 {
diff --git a/src/app/qgisapp.h b/src/app/qgisapp.h
index 895354ac95f..bb0aafdddf3 100644
--- a/src/app/qgisapp.h
+++ b/src/app/qgisapp.h
@@ -539,18 +539,30 @@ class APP_EXPORT QgisApp : public QMainWindow, private Ui::MainWindow
 
     QAction *actionDataSourceManager() { return mActionDataSourceManager; }
     QAction *actionNewVectorLayer() { return mActionNewVectorLayer; }
+#ifdef HAVE_SPATIALITE
     QAction *actionNewSpatialLiteLayer() { return mActionNewSpatiaLiteLayer; }
+#else
+    QAction *actionNewSpatialLiteLayer() { return nullptr; }
+#endif
     QAction *actionEmbedLayers() { return mActionEmbedLayers; }
     QAction *actionAddOgrLayer() { return mActionAddOgrLayer; }
     QAction *actionAddRasterLayer() { return mActionAddRasterLayer; }
     QAction *actionAddPgLayer() { return mActionAddPgLayer; }
+#ifdef HAVE_SPATIALITE
     QAction *actionAddSpatiaLiteLayer() { return mActionAddSpatiaLiteLayer; }
+#else
+    QAction *actionAddSpatiaLiteLayer() { return nullptr; }
+#endif
     QAction *actionAddWmsLayer() { return mActionAddWmsLayer; }
     QAction *actionAddXyzLayer() { return mActionAddXyzLayer; }
     QAction *actionAddVectorTileLayer() { return mActionAddVectorTileLayer; }
     QAction *actionAddPointCloudLayer() { return mActionAddPointCloudLayer; }
     QAction *actionAddWcsLayer() { return mActionAddWcsLayer; }
+#ifdef HAVE_SPATIALITE
     QAction *actionAddWfsLayer() { return mActionAddWfsLayer; }
+#else
+    QAction *actionAddWfsLayer() { return nullptr; }
+#endif
     QAction *actionAddAfsLayer() { return mActionAddAfsLayer; }
     QAction *actionCopyLayerStyle() { return mActionCopyStyle; }
     QAction *actionPasteLayerStyle() { return mActionPasteStyle; }
@@ -1561,8 +1573,10 @@ class APP_EXPORT QgisApp : public QMainWindow, private Ui::MainWindow
     void newVectorLayer();
     //! Create a new memory layer
     void newMemoryLayer();
+#ifdef HAVE_SPATIALITE
     //! Create a new empty SpatiaLite layer
     void newSpatialiteLayer();
+#endif
     //! Create a new empty GeoPackage layer
     void newGeoPackageLayer();
 
diff --git a/src/core/CMakeLists.txt b/src/core/CMakeLists.txt
index 3016c79d1e6..fb0de5229b8 100644
--- a/src/core/CMakeLists.txt
+++ b/src/core/CMakeLists.txt
@@ -1774,7 +1774,6 @@ target_include_directories(qgis_core SYSTEM PUBLIC
   ${GEOS_INCLUDE_DIR}
   ${EXPAT_INCLUDE_DIR}
   ${SQLITE3_INCLUDE_DIR}
-  ${SPATIALITE_INCLUDE_DIR}
   ${QCA_INCLUDE_DIR}
   ${QTKEYCHAIN_INCLUDE_DIR}
   ${${QT_VERSION_BASE}SerialPort_INCLUDE_DIRS}
@@ -1782,6 +1781,12 @@ target_include_directories(qgis_core SYSTEM PUBLIC
   ${ZLIB_INCLUDE_DIRS}
 )
 
+if (WITH_SPATIALITE)
+  target_include_directories(qgis_core SYSTEM PUBLIC
+    ${SPATIALITE_INCLUDE_DIR}
+  )
+endif()
+
 target_include_directories(qgis_core PUBLIC
   ${CMAKE_CURRENT_SOURCE_DIR}
   ${CMAKE_CURRENT_BINARY_DIR}
@@ -1941,12 +1946,15 @@ target_link_libraries(qgis_core
   ${SPATIALINDEX_LIBRARY}
   ${EXPAT_LIBRARY}
   ${SQLITE3_LIBRARY}
-  ${SPATIALITE_LIBRARY}
   ${LIBZIP_LIBRARY}
   ${Protobuf_LITE_LIBRARY}
   ${ZLIB_LIBRARIES}
 )
 
+if (WITH_SPATIALITE)
+  target_link_libraries(qgis_core ${SPATIALITE_LIBRARY})
+endif()
+
 if (WITH_QT6)
   target_link_libraries(qgis_core Qt6::Core5Compat)
 endif()
diff --git a/src/core/qgsofflineediting.cpp b/src/core/qgsofflineediting.cpp
index 2fa39065f9b..75a221589f5 100644
--- a/src/core/qgsofflineediting.cpp
+++ b/src/core/qgsofflineediting.cpp
@@ -53,8 +53,14 @@
 extern "C"
 {
 #include <sqlite3.h>
+}
+
+#ifdef HAVE_SPATIALITE
+extern "C"
+{
 #include <spatialite.h>
 }
+#endif
 
 #define CUSTOM_PROPERTY_IS_OFFLINE_EDITABLE "isOfflineEditable"
 #define CUSTOM_PROPERTY_REMOTE_SOURCE "remoteSource"
@@ -368,6 +374,7 @@ void QgsOfflineEditing::synchronize()
 
 void QgsOfflineEditing::initializeSpatialMetadata( sqlite3 *sqlite_handle )
 {
+#ifdef HAVE_SPATIALITE
   // attempting to perform self-initialization for a newly created DB
   if ( !sqlite_handle )
     return;
@@ -425,6 +432,9 @@ void QgsOfflineEditing::initializeSpatialMetadata( sqlite3 *sqlite_handle )
     return;
   }
   spatial_ref_sys_init( sqlite_handle, 0 );
+#else
+  ( void )sqlite_handle;
+#endif
 }
 
 bool QgsOfflineEditing::createOfflineDb( const QString &offlineDbPath, ContainerType containerType )
@@ -557,6 +567,7 @@ QgsVectorLayer *QgsOfflineEditing::copyVectorLayer( QgsVectorLayer *layer, sqlit
   {
     case SpatiaLite:
     {
+#ifdef HAVE_SPATIALITE
       // create table
       QString sql = QStringLiteral( "CREATE TABLE '%1' (" ).arg( tableName );
       QString delim;
@@ -669,7 +680,13 @@ QgsVectorLayer *QgsOfflineEditing::copyVectorLayer( QgsVectorLayer *layer, sqlit
       newLayer = new QgsVectorLayer( connectionString,
                                      layer->name() + layerNameSuffix, QStringLiteral( "spatialite" ), options );
       break;
+
+#else
+      showWarning( tr( "No Spatialite support available" ) );
+      return nullptr;
+#endif
     }
+
     case GPKG:
     {
       // Set options
diff --git a/src/core/qgsspatialiteutils.cpp b/src/core/qgsspatialiteutils.cpp
index e9e1950b149..9c721d9b1d9 100644
--- a/src/core/qgsspatialiteutils.cpp
+++ b/src/core/qgsspatialiteutils.cpp
@@ -20,7 +20,10 @@
 #include "qgslogger.h"
 
 #include <sqlite3.h>
+
+#ifdef HAVE_SPATIALITE
 #include <spatialite.h>
+#endif
 
 // Define this variable to print all spatialite SQL statements
 #ifdef SPATIALITE_PRINT_ALL_SQL
@@ -40,15 +43,19 @@ static int trace_callback( unsigned, void *ctx, void *p, void * )
 
 int spatialite_database_unique_ptr::open( const QString &path )
 {
+#ifdef HAVE_SPATIALITE
   auto &deleter = get_deleter();
   deleter.mSpatialiteContext = spatialite_alloc_connection();
+#endif
 
   sqlite3 *database = nullptr;
   int result = sqlite3_open( path.toUtf8(), &database );
   std::unique_ptr< sqlite3, QgsSpatialiteCloser>::reset( database );
 
+#ifdef HAVE_SPATIALITE
   if ( result == SQLITE_OK )
     spatialite_init_ex( database, deleter.mSpatialiteContext, 0 );
+#endif
 
   return result;
 }
@@ -60,15 +67,19 @@ void spatialite_database_unique_ptr::reset()
 
 int spatialite_database_unique_ptr::open_v2( const QString &path, int flags, const char *zVfs )
 {
+#ifdef HAVE_SPATIALITE
   auto &deleter = get_deleter();
   deleter.mSpatialiteContext = spatialite_alloc_connection();
+#endif
 
   sqlite3 *database = nullptr;
   int result = sqlite3_open_v2( path.toUtf8(), &database, flags, zVfs );
   std::unique_ptr< sqlite3, QgsSpatialiteCloser>::reset( database );
 
+#ifdef HAVE_SPATIALITE
   if ( result == SQLITE_OK )
     spatialite_init_ex( database, deleter.mSpatialiteContext, 0 );
+#endif
 
 #ifdef SPATIALITE_PRINT_ALL_SQL
   // Log all queries
@@ -107,6 +118,8 @@ void QgsSpatialiteCloser::operator()( sqlite3 *handle )
     QgsDebugMsg( QStringLiteral( "sqlite3_close_v2() failed: %1" ).arg( res ) );
   }
 
+#ifdef HAVE_SPATIALITE
   spatialite_cleanup_ex( mSpatialiteContext );
+#endif
   mSpatialiteContext = nullptr;
 }
diff --git a/src/plugins/CMakeLists.txt b/src/plugins/CMakeLists.txt
index 7629f9982f7..e4049231e25 100644
--- a/src/plugins/CMakeLists.txt
+++ b/src/plugins/CMakeLists.txt
@@ -8,9 +8,12 @@ set (CMAKE_LIBRARY_OUTPUT_DIRECTORY ${QGIS_OUTPUT_DIRECTORY}/${QGIS_PLUGIN_SUBDI
 
 add_subdirectory(gps_importer)
 add_subdirectory(topology)
-add_subdirectory(offline_editing)
 add_subdirectory(geometry_checker)
 
+if (WITH_SPATIALITE)
+  add_subdirectory(offline_editing)
+endif()
+
 if (GRASS_FOUND)
   add_subdirectory(grass)
 endif()
diff --git a/src/providers/CMakeLists.txt b/src/providers/CMakeLists.txt
index aa9af311115..d371ae3c817 100644
--- a/src/providers/CMakeLists.txt
+++ b/src/providers/CMakeLists.txt
@@ -16,12 +16,15 @@ if (NOT FORCE_STATIC_PROVIDERS)
   add_subdirectory(ows)
   add_subdirectory(wcs)
   add_subdirectory(gpx)
-  add_subdirectory(wfs)
-  add_subdirectory(spatialite)
-  add_subdirectory(virtual)
   add_subdirectory(db2)
   add_subdirectory(mdal)
 
+  if (WITH_SPATIALITE)
+    add_subdirectory(spatialite)
+    add_subdirectory(virtual)
+    add_subdirectory(wfs)
+  endif()
+
   if (WITH_ORACLE)
     add_subdirectory(oracle)
   endif()