diff --git a/python/pyplugin_installer/installer_data.py b/python/pyplugin_installer/installer_data.py
index e15d1ddbe86..bcf1488dc2f 100644
--- a/python/pyplugin_installer/installer_data.py
+++ b/python/pyplugin_installer/installer_data.py
@@ -30,7 +30,7 @@ from typing import (
 
 from qgis.PyQt.QtCore import (pyqtSignal, QObject, QCoreApplication, QFile,
                               QDir, QDirIterator, QDate, QUrl, QFileInfo,
-                              QLocale, QByteArray)
+                              QLocale, QByteArray, QT_VERSION_STR)
 from qgis.PyQt.QtXml import QDomDocument
 from qgis.PyQt.QtNetwork import QNetworkRequest, QNetworkReply
 from qgis.core import Qgis, QgsSettings, QgsSettingsTree, QgsNetworkRequestParameters
@@ -438,9 +438,11 @@ class Repositories(QObject):
                     qgisMaximumVersion = pluginNodes.item(i).firstChildElement("qgis_maximum_version").text().strip()
                     if not qgisMaximumVersion:
                         qgisMaximumVersion = qgisMinimumVersion[0] + ".99"
+                    supports_qt6 = pluginNodes.item(i).firstChildElement("supports_qt6").text().strip().upper() in ("TRUE", "YES")
+                    qt_version = int(QT_VERSION_STR.split('.')[0])
                     # if compatible, add the plugin to the list
                     if not pluginNodes.item(i).firstChildElement("disabled").text().strip().upper() in ["TRUE", "YES"]:
-                        if isCompatible(pyQgisVersion(), qgisMinimumVersion, qgisMaximumVersion):
+                        if isCompatible(pyQgisVersion(), qgisMinimumVersion, qgisMaximumVersion) and (qt_version != 6 or supports_qt6):
                             # add the plugin to the cache
                             plugins.addFromRepository(plugin)
                 self.mRepositories[reposName]["state"] = Repositories.STATE_LOADED
@@ -585,7 +587,12 @@ class Plugins(QObject):
         if os.path.exists(metadataFile):
             version = normalizeVersion(pluginMetadata("version"))
 
-        if version:
+        qt_version = int(QT_VERSION_STR.split('.')[0])
+        supports_qt6 = pluginMetadata("supportsQt6").strip().upper() in ("TRUE", "YES")
+        if qt_version == 6 and not supports_qt6:
+            error = "incompatible"
+            errorDetails = QCoreApplication.translate("QgsPluginInstaller", "Plugin does not support Qt6 versions of QGIS")
+        elif version:
             qgisMinimumVersion = pluginMetadata("qgisMinimumVersion").strip()
             if not qgisMinimumVersion:
                 qgisMinimumVersion = "0"
diff --git a/src/app/qgspluginregistry.cpp b/src/app/qgspluginregistry.cpp
index c020c345302..b35903fbbf2 100644
--- a/src/app/qgspluginregistry.cpp
+++ b/src/app/qgspluginregistry.cpp
@@ -721,6 +721,13 @@ bool QgsPluginRegistry::checkPythonPlugin( const QString &packageName )
 bool QgsPluginRegistry::isPythonPluginCompatible( const QString &packageName ) const
 {
 #ifdef WITH_BINDINGS
+#if QT_VERSION >= QT_VERSION_CHECK(6, 0, 0)
+  const QString supportsQt6 = mPythonUtils->getPluginMetadata( packageName, QStringLiteral( "supportsQt6" ) ).trimmed();
+  if ( supportsQt6.compare( QLatin1String( "YES" ), Qt::CaseInsensitive ) != 0 && supportsQt6.compare( QLatin1String( "TRUE" ), Qt::CaseInsensitive ) != 0 )
+  {
+    return false;
+  }
+#endif
   const QString minVersion = mPythonUtils->getPluginMetadata( packageName, QStringLiteral( "qgisMinimumVersion" ) );
   // try to read qgisMaximumVersion. Note checkQgisVersion can cope with "__error__" value.
   const QString maxVersion = mPythonUtils->getPluginMetadata( packageName, QStringLiteral( "qgisMaximumVersion" ) );