diff --git a/rpm/qgis.spec.template b/rpm/qgis.spec.template
index 4e62db3f4d6..1cd6a2bc564 100644
--- a/rpm/qgis.spec.template
+++ b/rpm/qgis.spec.template
@@ -92,32 +92,32 @@ BuildRequires:  python3-jinja2
 BuildRequires:  python3-OWSLib
 BuildRequires:  python3-psycopg2
 BuildRequires:  python3-pygments
+BuildRequires:  python3-pyqt6-devel
 BuildRequires:  python3-PyYAML
-BuildRequires:  python3-qscintilla-qt5
-BuildRequires:  python3-qscintilla-qt5-devel
-BuildRequires:  python3-qt5-devel
+BuildRequires:  python3-qscintilla-qt6
+BuildRequires:  python3-qscintilla-qt6-devel
 BuildRequires:  sip6
 BuildRequires:  PyQt-builder
 
 # Qca stuff
-BuildRequires:  qca-qt5-devel
-BuildRequires:  qca-qt5-ossl
-BuildRequires:  qscintilla-qt5-devel
+BuildRequires:  qca-qt6-devel
+BuildRequires:  qca-qt6-ossl
+BuildRequires:  qscintilla-qt6-devel
 
-# Qt5 stuff
-BuildRequires:  cmake(Qt5WebEngine)
-BuildRequires:  qt5-qtlocation-devel
-BuildRequires:  qt5-qtmultimedia-devel
-BuildRequires:  qt5-qtsvg-devel
-BuildRequires:  qt5-qttools-static
-BuildRequires:  qt5-qtwebkit-devel
-BuildRequires:  qtkeychain-qt5-devel
-BuildRequires:  qt5-qtserialport-devel
-BuildRequires:  qt5-qt3d-devel
-BuildRequires:  qt5-qtbase-private-devel
+# Qt stuff
+BuildRequires:  qt6-qt3d-devel
+BuildRequires:  qt6-qt5compat-devel
+BuildRequires:  qt6-qtbase-private-devel
+BuildRequires:  qt6-qtlocation-devel
+BuildRequires:  qt6-qtmultimedia-devel
+BuildRequires:  qt6-qtserialport-devel
+BuildRequires:  qt6-qtsvg-devel
+BuildRequires:  qt6-qttools-static
+BuildRequires:  qt6-qtwebengine-devel
+BuildRequires:  qtkeychain-qt6-devel
 
 # Qwt stuff
-BuildRequires:  qwt-qt5-devel
+BuildRequires:  qwt-qt6-devel
 
 # PDF4QT
 BuildRequires:  pkgconfig(freetype2)
@@ -130,10 +130,10 @@ BuildRequires:  pkgconfig(libopenjp2)
 Requires:       gdal
 
 # Installation of QCA plugins must be explicit
-Requires:       qca-qt5-ossl
+Requires:       qca-qt6-ossl
 Requires:       gpsbabel
 Requires:       PDAL
-Requires:       qt5-qtcharts
+Requires:       qt6-qtcharts
 
 # We don't want to provide private Python extension libs
 %global __provides_exclude_from ^(%{python3_sitearch}|%{_libdir}/%{name}/plugins)/.*\.so(\.%{version})?$
@@ -181,10 +181,10 @@ Requires:       python3-OWSLib
 Requires:       python3-packaging
 Requires:       python3-psycopg2
 Requires:       python3-pygments
+Requires:       python3-pyqt6
 Requires:       python3-PyYAML
-Requires:       python3-qscintilla-qt5
-Requires:       python3-qt5
-%{?_sip_api:Requires: python3-pyqt5-sip-api(%{_sip_api_major}) >= %{_sip_api}}
+Requires:       python3-qscintilla-qt6
+%{?_sip_api:Requires: python3-pyqt6-sip-api(%{_sip_api_major}) >= %{_sip_api}}
 
 %description -n python3-qgis
 Python integration and plug-ins for QGIS.
@@ -224,6 +224,7 @@ gzip ChangeLog
 %build
 %cmake \
       %{_cmake_skip_rpath} \
+      -D BUILD_WITH_QT6:BOOL=TRUE \
       -D QGIS_LIB_SUBDIR=%{_lib} \
       -D QGIS_MANUAL_SUBDIR=/share/man \
       -D QGIS_CGIBIN_SUBDIR=%{_libexecdir}/%{name} \
@@ -238,6 +239,7 @@ gzip ChangeLog
       -D WITH_PDF4QT:BOOL=TRUE \
       -D WITH_QSPATIALITE:BOOL=TRUE \
       -D WITH_QTWEBENGINE:BOOL=TRUE \
+      -D WITH_QTWEBKIT:BOOL=FALSE \
       -D WITH_SERVER:BOOL=TRUE \
       -D WITH_3D:BOOL=TRUE \
       -D USE_OPENCL:BOOL=TRUE \
@@ -280,7 +282,7 @@ rm -f %{buildroot}%{_datadir}/%{name}/doc/INSTALL*
 %{_libdir}/lib%{name}_3d.so.*
 %{_libdir}/libPdf4QtLibCore.so*
 %{_libdir}/%{name}/
-%{?_qt5_plugindir}/sqldrivers/libqsqlspatialite.so
+%{?_qt6_plugindir}/sqldrivers/libqsqlspatialite.so
 %{_bindir}/%{name}
 %{_bindir}/%{name}_process
 %{_mandir}/man1/%{name}.1*
@@ -304,7 +306,7 @@ rm -f %{buildroot}%{_datadir}/%{name}/doc/INSTALL*
 %{_datadir}/%{name}/FindQGIS.cmake
 %{_includedir}/%{name}/
 %{_libdir}/lib%{name}*.so
-%{?_qt5_plugindir}/designer/libqgis_customwidgets.so*
+%{?_qt6_plugindir}/designer/libqgis_customwidgets.so*
 
 %files grass
 %{_libdir}/lib%{name}grass*.so.*
@@ -318,7 +320,7 @@ rm -f %{buildroot}%{_datadir}/%{name}/doc/INSTALL*
 %{_libdir}/libqgispython.so.*
 %{_datadir}/%{name}/python/
 %{python3_sitearch}/%{name}/
-%{python3_sitearch}/PyQt5/uic/widget-plugins/
+%{python3_sitearch}/PyQt6/uic/widget-plugins/
 %exclude %{python3_sitearch}/%{name}/server/
 %exclude %{python3_sitearch}/%{name}/_server.so