diff --git a/configure b/configure
index c864825785c..4c5629d53af 100755
--- a/configure
+++ b/configure
@@ -4474,6 +4474,73 @@ fi
   if test -n "$NOT_THE_CFLAGS"; then
     CFLAGS="$CFLAGS -Wno-unused-command-line-argument"
   fi
+  # Remove clang 12+'s compound-token-split-by-macro, as this causes a lot
+  # of warnings when building plperl because of Perl.  Like previously, test
+  # for the positive form and add the negative form
+  NOT_THE_CFLAGS=""
+  { $as_echo "$as_me:$LINENO: checking whether $CC supports -Wcompound-token-split-by-macro" >&5
+$as_echo_n "checking whether $CC supports -Wcompound-token-split-by-macro... " >&6; }
+if test "${pgac_cv_prog_cc_cflags__Wcompound_token_split_by_macro+set}" = set; then
+  $as_echo_n "(cached) " >&6
+else
+  pgac_save_CFLAGS=$CFLAGS
+CFLAGS="$pgac_save_CFLAGS -Wcompound-token-split-by-macro"
+ac_save_c_werror_flag=$ac_c_werror_flag
+ac_c_werror_flag=yes
+cat >conftest.$ac_ext <<_ACEOF
+/* confdefs.h.  */
+_ACEOF
+cat confdefs.h >>conftest.$ac_ext
+cat >>conftest.$ac_ext <<_ACEOF
+/* end confdefs.h.  */
+
+int
+main ()
+{
+
+  ;
+  return 0;
+}
+_ACEOF
+rm -f conftest.$ac_objext
+if { (ac_try="$ac_compile"
+case "(($ac_try" in
+  *\"* | *\`* | *\\*) ac_try_echo=\$ac_try;;
+  *) ac_try_echo=$ac_try;;
+esac
+eval ac_try_echo="\"\$as_me:$LINENO: $ac_try_echo\""
+$as_echo "$ac_try_echo") >&5
+  (eval "$ac_compile") 2>conftest.er1
+  ac_status=$?
+  grep -v '^ *+' conftest.er1 >conftest.err
+  rm -f conftest.er1
+  cat conftest.err >&5
+  $as_echo "$as_me:$LINENO: \$? = $ac_status" >&5
+  (exit $ac_status); } && {
+	 test -z "$ac_c_werror_flag" ||
+	 test ! -s conftest.err
+       } && test -s conftest.$ac_objext; then
+  pgac_cv_prog_cc_cflags__Wcompound_token_split_by_macro=yes
+else
+  $as_echo "$as_me: failed program was:" >&5
+sed 's/^/| /' conftest.$ac_ext >&5
+
+	pgac_cv_prog_cc_cflags__Wcompound_token_split_by_macro=no
+fi
+
+rm -f core conftest.err conftest.$ac_objext conftest.$ac_ext
+ac_c_werror_flag=$ac_save_c_werror_flag
+CFLAGS="$pgac_save_CFLAGS"
+fi
+{ $as_echo "$as_me:$LINENO: result: $pgac_cv_prog_cc_cflags__Wcompound_token_split_by_macro" >&5
+$as_echo "$pgac_cv_prog_cc_cflags__Wcompound_token_split_by_macro" >&6; }
+if test x"$pgac_cv_prog_cc_cflags__Wcompound_token_split_by_macro" = x"yes"; then
+  NOT_THE_CFLAGS="${NOT_THE_CFLAGS} -Wcompound-token-split-by-macro"
+fi
+
+  if test -n "$NOT_THE_CFLAGS"; then
+    CFLAGS="$CFLAGS -Wno-compound-token-split-by-macro"
+  fi
   # Similarly disable useless truncation warnings from gcc 8+
   NOT_THE_CFLAGS=""
   { $as_echo "$as_me:$LINENO: checking whether $CC supports -Wformat-truncation" >&5
diff --git a/configure.in b/configure.in
index d030f83f796..3314fd98a15 100644
--- a/configure.in
+++ b/configure.in
@@ -434,6 +434,14 @@ if test "$GCC" = yes -a "$ICC" = no; then
   if test -n "$NOT_THE_CFLAGS"; then
     CFLAGS="$CFLAGS -Wno-unused-command-line-argument"
   fi
+  # Remove clang 12+'s compound-token-split-by-macro, as this causes a lot
+  # of warnings when building plperl because of Perl.  Like previously, test
+  # for the positive form and add the negative form
+  NOT_THE_CFLAGS=""
+  PGAC_PROG_CC_VAR_OPT(NOT_THE_CFLAGS, [-Wcompound-token-split-by-macro])
+  if test -n "$NOT_THE_CFLAGS"; then
+    CFLAGS="$CFLAGS -Wno-compound-token-split-by-macro"
+  fi
   # Similarly disable useless truncation warnings from gcc 8+
   NOT_THE_CFLAGS=""
   PGAC_PROG_CC_VAR_OPT(NOT_THE_CFLAGS, [-Wformat-truncation])